Scientist I, Affinity Selection, Library Discovery

Position
We are seeking a highly skilled and motivated Scientist with expertise in protein sciences and affinity selection methodologies to join Nurix’s Library Discovery team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in the areas of oncology and immuno-oncology, by utilizing mechanistic and structural insights to guide drug discovery efforts.

Primary Functions

The successful candidate will utilize DNA encoded libraries to identify novel, physiologically relevant chemical matter for a variety of targets within Nurix’s discovery pipeline. This person will also play a key role in discovery by evolving the standard paradigm of encoded library selection toward more extensive and mechanism-directed selection campaigns that exploit existing biophysical and mutation information. This individual will work closely with an interdisciplinary team of discovery scientists, all of whom have regular opportunities present findings to the project team and senior management. The candidate should have a strong desire to learn new techniques and the ability to incorporate new methodologies into their work. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.

Qualifications

  • Ph.D. in Biochemistry or related field with 0-3 years post-degree industry experience.
  • Expertise in DNA encoded library affinity selection or related methodologies (phage display or SELEX, etc…).
  • Experience in using biophysical techniques to analyze protein-protein interactions as well as protein-small molecule interactions.
  • Hands on experience performing biochemical assays.
  • Experience with protein expression and purification, ideally with multiprotein complexes.
  • A strong track record (publications or industry experience) with excellent interpersonal skills and ability to work in a team environment.
  • The successful candidate will be aligned to Nurix’s culture and values; he/she will be team oriented and highly collaborative with a hands-on approach.
  • The candidate should be enthusiastic, driven, and have the ability to work independently and thrive in a dynamic start-up environment.

Application Process Please include a two page research summary with your CV.


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Senior Scientist, DNA Encoded Chemistry, Library Discovery

Position
We are seeking a talented and highly motivated Scientist with a strong background in synthetic organic chemistry, medicinal chemistry and/or DNA encoded chemistry to lead our library group in the pursuit of novel small molecules to treat patients with unmet medical needs. Specifically, this individual will lead a small group whose primary focus will be to design and synthesize DNA encoded libraries and utilize these libraries to identify novel chemical matter with the potential to modulate our key targets. The successful candidate will have demonstrated experience in evaluating and prioritizing chemical features for hit to lead studies.

Primary Functions

A key responsibility will be to integrate with the existing medicinal chemistry team to rapidly scan outputs for drug-like hits that can be further optimized for potency, selectivity, pharmacokinetics and in vivo efficacy. As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators. Additionally, they will contribute effectively to patent, report and scientific publication writing.

Qualifications

  • Ph.D. in synthetic organic chemistry with 8+ years industrial chemistry or medicinal chemistry experience. Experience in parallel synthesis is highly preferred.
  • High level of creativity and productivity with strong synthetic problem solving skills.
  • Excellent scientific expertise in organic synthesis and familiarity with aqueous chemistry, conversant with the current literature.
  • Proven leadership capability in cross-functional team setting, either as project team leader or co-lead.
  • Ability and interest to innovate in both library chemistry and design.
  • Solid appreciation of the sample management and logistics required for successful combinatorial library synthesis.
  • Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents and meetings and using this information to guide program strategy
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.
  • Solid track record of innovation and impact on programs, with direct contributions to company pipelines (including both successful advances and smart terminations).
  • Experience in utilization of linker technology and chemical biology probes a plus

Please include a two-page research summary that highlights the above required qualifications.


Apply

Scientist I, Medicinal Chemistry

Position
We are seeking a talented and highly motivated individual with a strong background in synthetic organic chemistry for an opening we have for a Scientist I in our Medicinal Chemistry group.

Primary Functions

The successful candidate will engage in rational structure based drug discovery enabled by our computational and structural biology group. Specifically, this individual will design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics and in vivo efficacy. As a member of a dynamic multi-disciplinary project team, she/he will collaborate with a broad group of scientists within Nurix and with external collaborators. Additionally, she/he will contribute effectively to patent, report and scientific publication writing.

Qualifications

  • Ph.D. in synthetic organic chemistry (relevant postdoctoral and/or 1-3 years pharmaceutical medicinal chemistry industrial experience is a plus)
  • Proven track record of innovative project contributions including peer-reviewed publications.
  • High level of creativity and productivity with strong synthetic problem solving skills.
  • Excellent scientific expertise in organic synthesis, conversant with the current literature.
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.
  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view


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Scientific Data Analyst, Informatics

Position

We are seeking a highly skilled and motivated Scientist to lead and support implementing data assessment and decision systems for biological assays: High-throughput Screening (HTS), in vitro and cellular, in vitro and in vivo ADME and toxicology. This person will establish and support the models and processes used to assess the quality of data, the statistical methods to apply, the criteria for selection of hits, and the capture of decisions why particular methods were selected. This individual will work closely with a team of interdisciplinary scientists and will provide insights to other scientist in order to leverage scientific and information systems to record and drive team decisions. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.

Primary Functions

  • Understand raw data from low-throughput in vitro and high-throughput screening (HTS) assays
  • Create automated scripts to process assay data into analysis-ready results including consideration to outliers, edge effects, controls, and methods to calculate IC50 and EC50
  • Assist scientists with statistical analysis and interpretation of results into decisions, including pass/fail of target hit, compound confirmation, and activities in counter screens
  • Develop, refine, and deploy models to visualize single and multiple data sets in order to streamline the decision-making process with scientists and leaders
  • Present meaningful, easy-to-understand, consistent visualizations incorporating statistical assessment of data quality with comparisons among methods, data sets, and assay conditions
  • Analyze historical trends across targets and share insight into classes of action and promiscuity
  • Discuss/Document workflow and requirements of scientists into action items
  • Assist in the proper storage and retrieval of information to/from databases

Qualifications

  • Ph.D. in Computational Biology, Computer Science, Bioinformatics, Statistics, or related field with 3+ year’s post-degree experience. Master’s degree candidate with 8+ years’ experience would also be considered.
  • Experience with multivariate statistical techniques, algorithms, and packages to handle systematic and random error in multiple types of biological experiments and implement them in data analysis workflow
  • Knowledge of appropriate models to filter and fit multi-dimensional, chemical and assay data as well as assess the quality of the data being reviewed
  • Expertise in comprehensive data analysis with commercial scripting tools such as Pipeline Pilot and decision tools such as Dotmatics’ Vortex and TIBCO Spotfire
  • Ability to use statistical packages such as R, JMP, Minitab, and ProMV
  • Ability to code algorithms using formal (e.g., Java) or scripting (e.g., Python) languages
  • The successful candidate will be aligned to Nurix’ culture and values; he/she will be team oriented and highly collaborative with a hands-on approach
  • The candidate should be enthusiastic, driven, have the ability to work independently and thrive in a dynamic start-up environment


Apply

Scientist II/Senior Scientist,Preclinical Pharmacology, Discovery Biology

Position
We are seeking a highly skilled and motivated in vivo pharmacologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology.

Primary Functions

The ideal candidate will have expertise in small molecule PK/PD studies in oncology and/or immuno-oncology. This individual will work closely with our drug discovery project scientists on lead optimization of novel compounds to evaluate formulations, PK/PD relationships, toxicities, and MOA. The candidate must be self-driven, organized, able to work well with project scientists, and able to thrive in an exciting environment in a rapidly-growing company.

Qualifications

  • Ph.D. in pharmacology, immunology, cancer biology or related field with 8+ years of industry experience for Senior Scientist or 4+ years for Scientist II
  • Expertise in small molecule drug development and PK/PD assay technologies
  • Expertise with hit-to-lead optimization and establishment of PK/PD relationships
  • Experience optimizing compounds with a variety of pharmacokinetic and metabolic profiles
  • Experience managing preclinical toxicology studies and evaluating dosing regimens and formulations appropriate for early or late preclinical development
  • In vivo pharmacology expertise with tumor or autoimmunity models preferred
  • Writing preclinical reports or sections of IND a plus
  • Proven ability to manage junior scientists, external collaborations, and CROs
  • Excellent communication and presentation skills
  • Excellent interpersonal skills and ability to work productively in a highly dynamic environment


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Research Associate/Senior Research Associate, Lead Discovery

Position

We are seeking a highly skilled and motivated individual with strong expertise in Biochemistry to join our Lead Discovery team. The successful candidate will engage in establishing and supporting early drug discovery efforts targeting E3 ligases in the area of Oncology and Immuno-Oncology.

Primary Functions

This individual will conceive and conduct experiments to support lead compound identification and elucidate the mechanism of action of small molecule drug candidate targets in the ubiquitin proteasome system pathway. His/Her duties include planning, execution and analysis of in vitro biochemical screening and mechanistic assays to support small molecule discovery efforts for new and ongoing programs. He/she will work closely with scientists from cross-functional disciplines and present findings to project teams. The candidate should have a strong desire to learn new techniques and the ability to incorporate new methodologies into his/her work. The ideal candidate will be self-driven, highly organized, focused and enjoy working in a dynamic team environment.

Qualifications

  • For SRA: Master’s degree in Biochemistry, Cell and Molecular Biology, or related field with 6+ years industry experience (or Bachelor’s degree with 8+ years of industry experience)

  • For RA: Bachelor’s or Master’s degree with 2-5 years of industry experience

  • Strong background with hands-on experience in development, optimization and execution of various biochemical binding and activity assays including FP and FRET

  • Prior experience in small molecule screening, liquid handling instruments and data analysis

  • Familiarity with general biochemical and molecular biology techniques including protein expression and purification to support downstream mechanism of action and target occupancy readouts for drug candidates

  • Previous experience in ubiquitin biology is a plus

  • The successful candidate will be strongly aligned to Nurix’s culture and values; he/she will be team-oriented and highly collaborative with a hands-on approach


Apply

Nurix, Inc. is a science-focused and goal-oriented organization that is committed to bringing breakthrough therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein homeostasis – a function vital to the healthy life of a cell – offering therapeutic opportunities in multiple disease areas. The Nurix scientific team has established an innovative drug discovery platform to identify selective inhibitors or activators of the UPS, enabling the development of new class of drugs that can restore normal cellular protein homeostasis. Nurix was founded by internationally-recognized experts in the UPS field and received its initial funding from leading life science investors, Third Rock Ventures and The Column Group. The Company recently entered into a multi-year strategic collaboration with Celgene for the discovery and development of new therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology. Nurix is based in San Francisco, California.

We are an equal opportunity employer offering a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the US. Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited