Senior Scientist, Proteomics, Lead Discovery

Position

We are seeking highly skilled Senior Scientist with expertise in Proteomics to join Nurix’s Discovery team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in oncology, immune-oncology and other therapeutic areas. The successful candidate will support Nurix’s drug discovery program and play a leading role in building and implementing proteomics capabilities. This individual will work closely with an experienced team of interdisciplinary scientists and will have regular opportunities to present findings and opinions to project teams and senior management. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.

Primary Functions

  • Build and run in-house mass spectroscopy-based proteomics capabilities to identify and characterize proteins and their post-translational modification
  • Utilize mass spectrometry techniques for protein identification and quantification for various sample types including complex mixtures using label-free and label-based techniques
  • Implement new technologies, and develop proteomics workflows including sample preparation and data analyses
  • Design proteomics-based experiments together with the project team, and lead the execution, analyses and interpretation of results
  • Make recommendations, maintain and troubleshoot mass spectrometers

Qualifications

  • Ph.D. in Biochemistry, Cell or Molecular Biology, Chemical Biology or related field with 6+ years post-degree industry experience
  • Demonstrated expertise in operating relevant mass spectrometer instruments (e.g., from Agilent, Sciex and Thermo)
  • Demonstrated experience in designing, executing and analyzing quantitative proteomics experiments (e.g., protein abundance by SILAC and TMT)
  • Experience identifying and localizing post-translational modifications including phosphorylation and ubiquitylation from purified samples to complex mixtures
  • Knowledge of computational methods to analyze diverse mass spectroscopy datasets including quantification, post-translational modifications and discovery
  • A proven track record (e.g., publication, industry experience, etc.) with excellent interpersonal skills and ability to work in a team environment
  • The successful candidate will be strongly aligned to Nurix’s culture and values; he/she will be team-oriented and highly collaborative with a hands-on approach
  • The candidate should be enthusiastic, driven, have the ability to work independently and thrive in a dynamic start-up environment


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Scientific Data Analyst, Informatics

Position

We are seeking a highly skilled and motivated Scientist to lead and support implementing data assessment and decision systems for biological assays: High-throughput Screening (HTS), in vitro and cellular, in vitro and in vivo ADME and toxicology. This person will establish and support the models and processes used to assess the quality of data, the statistical methods to apply, the criteria for selection of hits, and the capture of decisions why particular methods were selected. This individual will work closely with a team of interdisciplinary scientists and will provide insights to other scientist in order to leverage scientific and information systems to record and drive team decisions. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.

Primary Functions

  • Understand raw data from low-throughput in vitro and high-throughput screening (HTS) assays
  • Create automated scripts to process assay data into analysis-ready results including consideration to outliers, edge effects, controls, and methods to calculate IC50 and EC50
  • Assist scientists with statistical analysis and interpretation of results into decisions, including pass/fail of target hit, compound confirmation, and activities in counter screens
  • Develop, refine, and deploy models to visualize single and multiple data sets in order to streamline the decision-making process with scientists and leaders
  • Present meaningful, easy-to-understand, consistent visualizations incorporating statistical assessment of data quality with comparisons among methods, data sets, and assay conditions
  • Analyze historical trends across targets and share insight into classes of action and promiscuity
  • Discuss/Document workflow and requirements of scientists into action items
  • Assist in the proper storage and retrieval of information to/from databases

Qualifications

  • Ph.D. in Computational Biology, Computer Science, Bioinformatics, Statistics, or related field with 3+ year’s post-degree experience. Master’s degree candidate with 8+ years’ experience would also be considered.
  • Experience with multivariate statistical techniques, algorithms, and packages to handle systematic and random error in multiple types of biological experiments and implement them in data analysis workflow
  • Knowledge of appropriate models to filter and fit multi-dimensional, chemical and assay data as well as assess the quality of the data being reviewed
  • Expertise in comprehensive data analysis with commercial scripting tools such as Pipeline Pilot and decision tools such as Dotmatics’ Vortex and TIBCO Spotfire
  • Ability to use statistical packages such as R, JMP, Minitab, and ProMV
  • Ability to code algorithms using formal (e.g., Java) or scripting (e.g., Python) languages
  • The successful candidate will be aligned to Nurix’ culture and values; he/she will be team oriented and highly collaborative with a hands-on approach
  • The candidate should be enthusiastic, driven, have the ability to work independently and thrive in a dynamic start-up environment


Apply

Senior Research Associate, Affinity Selection, Library Discovery

Position
We are seeking a highly skilled and motivated Scientist with expertise in molecular biology, protein sciences and affinity selection methodologies to join Nurix’s Library Discovery team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in the areas of oncology and immuno-oncology, by utilizing mechanistic and structural insights to guide drug discovery efforts.

Primary Functions

The successful candidate will have expertise in molecular biology and protein protein production, purification, and affinity selection and will play a key role in utilizing DNA encoded libraries to identify novel, physiologically relevant chemical matter in accord with Nurix’s biophysical and structural expertise in the UPS space. This person will work directly with our existing biochemists and biologists to develop selection strategies and tools to enable library interrogation. This individual will be a member of a small team, working closely with several experienced groups of interdisciplinary scientists all of whom have regular opportunities present findings to the project team and senior management. The candidate should have a strong desire to learn new techniques and the ability to incorporate new methodologies into their work. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.

Qualifications

  • Masters in Biochemistry, Cell and Molecular Biology, or related field with 4+ years post-degree industry experience.
  • Expertise in a range of biochemical and cell-based assay methodologies.
  • Experience with protein production in bacterial, baculovirus and mammalian expression systems, familiarity with multiprotein complexes a plus.
  • Knowledge of expression platforms, purification systems and analytical techniques (e.g. Wave bioreactor, AKTA, HPLC/MS, TFF).
  • Familiarity with higher throughput methodologies for protein purification and affinity selection.
  • Experience with sample production and QC for capillary and NGS sequencing platforms.
  • A strong track record (publications, industry experience) with excellent interpersonal skills and ability to work in a team environment.
  • The successful candidate will be aligned to Nurix’s culture and values; he/she will be team oriented and highly collaborative with a hands-on approach.
  • The candidate should be enthusiastic, driven, and have the ability to work independently and thrive in a dynamic start-up environment


Apply

Scientist I, Affinity Selection, Library Discovery

Position
We are seeking a highly skilled and motivated Scientist with expertise in protein sciences and affinity selection methodologies to join Nurix’s Library Discovery team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in the areas of oncology and immuno-oncology, by utilizing mechanistic and structural insights to guide drug discovery efforts.

Primary Functions

The successful candidate will utilize DNA encoded libraries to identify novel, physiologically relevant chemical matter for a variety of targets within Nurix’s discovery pipeline. This person will also play a key role in discovery by evolving the standard paradigm of encoded library selection toward more extensive and mechanism-directed selection campaigns that exploit existing biophysical and mutation information. This individual will work closely with an interdisciplinary team of discovery scientists, all of whom have regular opportunities present findings to the project team and senior management. The candidate should have a strong desire to learn new techniques and the ability to incorporate new methodologies into their work. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.

Qualifications

  • Ph.D. in Biochemistry or related field with 0-3 years post-degree industry experience.
  • Expertise in DNA encoded library affinity selection or related methodologies (phage display or SELEX, etc…).
  • Experience in using biophysical techniques to analyze protein-protein interactions as well as protein-small molecule interactions.
  • Hands on experience performing biochemical assays.
  • Experience with protein expression and purification, ideally with multiprotein complexes.
  • A strong track record (publications or industry experience) with excellent interpersonal skills and ability to work in a team environment.
  • The successful candidate will be aligned to Nurix’s culture and values; he/she will be team oriented and highly collaborative with a hands-on approach.
  • The candidate should be enthusiastic, driven, and have the ability to work independently and thrive in a dynamic start-up environment.

Application Process Please include a two page research summary with your CV.


Apply

Senior Scientist, Affinity Selection, Library Discovery

Position
We are seeking a highly skilled and motivated Scientist with expertise in protein sciences and affinity selection methodologies to join Nurix’s Library Discovery team. The candidate should have a strong desire to learn new techniques and the ability to incorporate new methodologies into their work. The ideal candidate will have a strong team orientation and be highly collaborative, self-driven, resourceful, organized, and open to diverse points of view.

Primary Functions

The successful candidate will provide scientific leadership in utilizing DNA encoded libraries to identify novel, physiologically relevant chemical matter in accord with Nurix’s biophysical and structural expertise in the UPS space. This person will play a key role in discovery by participating in target selection and by evolving the standard paradigm of encoded library selection toward more extensive and mechanism-directed selection campaigns that exploit existing biophysical and mutation information. She or he will bring key affinity selection experience to a small team that will work closely with several experienced groups of interdisciplinary scientists, all of whom have regular opportunities present findings to the project team and senior management.

Qualifications

  • Ph.D. in Biochemistry, Cell and Molecular Biology, or related field with 8+ years post-degree academic or industry experience.
  • Expertise in affinity selection techniques (preferably using DNA encoded libraries, although phage display or SELEX experience is acceptable).
  • Hands-on molecular biology experience including custom qPCR assays, PCR, and NGS.
  • Expertise in using biophysical techniques to analyze protein-protein interactions as well as protein-small molecule interactions.
  • Expertise in a variety of biochemical and cell-based assay platforms.
  • Experience with protein expression and characterization in bacterial, baculovirus or mammalian expression systems, ideally including experience with multiprotein complexes.
  • A strong track record (publications, industry experience) with excellent interpersonal skills and ability to work in a team environment.
  • The successful candidate will be aligned to Nurix’s culture and values.
  • The candidate should be enthusiastic, driven, and have the ability to work independently and thrive in a dynamic start-up environment.

Application Process Please include a two page summary with you CV


Apply

Scientist I, DNA Encoded Chemistry, Library Discovery

Position
We are seeking talented and highly motivated chemist with a strong background in synthetic organic chemistry and familiarity with the application of DNA encoded chemistry to join our Library Discovery team. Specifically, this individual will join a small group whose primary focus will be to design and synthesize DNA encoded libraries and utilize these libraries to identify novel chemical matter with the potential to modulate the activity of UPS targets.

Primary Functions

The successful candidate will have demonstrated experience in synthetic organic chemistry and analytical methods. Experience with aqueous chemistry and/or linker chemistry related to the synthesis of drug conjugates is highly preferred. As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators.

Qualifications

  • Ph.D. in synthetic organic chemistry with 0-4 years industrial chemistry experience.
  • Expert in synthetic organic chemistry methods and analytical tools.
  • High level of creativity and productivity with strong synthetic problem solving skills.
  • Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.
  • Familiarity with principles of affinity selection, DNA encoded library technology, and/or SELEX
  • Experience Interest in developing novel chemical reactions and chemical library designs.
  • Experience with chemistry involving biological macromolecules, ie antibodies and oligonucleotides, linker technologies, or the design and synthesis of chemical biology probes a plus.


Apply

Senior Scientist, DNA Encoded Chemistry, Library Discovery

Position
We are seeking a talented and highly motivated Scientist with a strong background in synthetic organic chemistry and DNA encoded chemistry to lead our library group in the pursuit of novel small molecules to treat patients with unmet medical needs. Specifically, this individual will lead a small group whose primary focus will be to design and synthesize DNA encoded libraries and utilize these libraries to identify novel chemical matter with the potential to modulate our key targets. The successful candidate will have demonstrated experience in evaluating and prioritizing chemical features from affinity selection experiments.

Primary Functions

A key responsibility will be to integrate with the existing medicinal chemistry team to rapidly scan outputs for drug-like hits that can be further optimized for potency, selectivity, pharmacokinetics and in vivo efficacy. As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators. Additionally, they will contribute effectively to patents, reports and scientific publications.

Qualifications

  • Ph.D. in synthetic organic chemistry with 8+ years industrial chemistry experience.
  • High level of creativity and productivity with strong synthetic problem solving skills.
  • Excellent scientific expertise in organic synthesis and specifically aqueous chemistry, conversant with the current literature.
  • Proven leadership capability in cross-functional team setting, either as project team leader or co-lead.
  • Ability and interest to innovate in both library chemistry and design.
  • Solid appreciation of the sample management and logistics required for successful combinatorial library synthesis.
  • Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents and meetings and using this information to guide program strategy
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.
  • Solid track record of innovation and impact on programs, with direct contributions to company pipelines (including both successful advances and smart terminations).
  • Experience in utilization of linker technology and chemical biology probes a plus


Apply

Senior Scientist, Medicinal Chemistry

Position
We are seeking a talented and highly motivated individual with a strong background in synthetic organic chemistry to join our medicinal chemistry group in the pursuit of novel small molecules to treat patients with unmet medical needs.

Primary Functions

The successful candidate will engage in rational structure based drug discovery enabled by our computational and structural biology group. Specifically, this individual will design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics and in vivo efficacy. As members of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix and with external collaborators. Additionally, they will contribute effectively to patent, report and scientific publication writing.

Qualifications

  • Ph.D. in synthetic organic chemistry with 8+ years pharmaceutical medicinal chemistry industrial experience
  • Successful application of structure based drug design leading to advanced leads/ development candidates. Strong working knowledge of protein-ligand interactions, conformational and structural analysis, experienced in partnering closely with computational chemists through appropriate use of computational tools, models and visualization applications.
  • High level of creativity and productivity with strong synthetic problem solving skills
  • Excellent scientific expertise in organic synthesis, conversant with the current literature
  • Ability to champion the chemistry efforts into new directions to achieve project milestones.
  • Solid track record of innovation and impact on programs, with direct contributions to company pipelines (including both successful advances and smart terminations).
  • Proven leadership capability in cross-functional team setting, either as project team leader or co-lead.
  • Strong evidence of conceptual thinking and active follow through, recognized by establishing new projects or new directions within projects, new strategies and/or enabling technologies for drug discovery. Vigorous scientific curiosity evidenced by contributions to diverse medicinal chemistry strategies.


Apply

Scientist II, Medicinal Chemistry

Position
We are seeking talented and highly motivated individuals with a strong background in synthetic organic chemistry to join our medicinal chemistry group in the pursuit of novel small molecules to treat patients with unmet medical needs.

Primary Functions

The successful candidate will engage in rational structure based drug discovery enabled by our computational and structural biology group. Specifically, this individual will design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics and in vivo efficacy. As members of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix and with external collaborators. Additionally, they will contribute effectively to patent, report and scientific publication writing.

Qualifications

  • Ph.D. in synthetic organic chemistry with 4+ years pharmaceutical medicinal chemistry industrial experience
  • Successful application of structure based drug design leading to advanced leads/ development candidates. Strong working knowledge of protein-ligand interactions, conformational and structural analysis, experienced in partnering closely with computational chemists through appropriate use of computational tools, models and visualization applications.
  • Proven track record of innovative project contributions including peer-reviewed publications.
  • High level of creativity and productivity with strong synthetic problem solving skills.
  • Excellent scientific expertise in organic synthesis, conversant with the current literature.
  • Strong knowledge of medicinal chemistry principles with a solid understanding of key ADME, biochemical and pharmacological principles and able to effectively integrate and apply these to the optimization of multiple parameters during lead generation and lead optimization efforts.
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.
  • Ability to champion the chemistry efforts into new directions to achieve project milestones.


Apply

Scientist II/Senior Scientist, In Vivo Pharmacology, Discovery Biology

Position
We are seeking a highly skilled and motivated in vivo pharmacologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology.

Primary Functions

The ideal candidate will have expertise in small molecule PK/PD studies in oncology and/or inflammation. The Scientist II/Senior Scientist of In Vivo Pharmacology will work closely with our drug discovery project scientists on late-stage lead optimization of novel compounds to evaluate PK/PD relationships, in vivo efficacy and ex vivo immune cell function. The candidate must be self-driven, organized, able to work well with project scientists, and able to thrive in an exciting environment in a rapidly-growing company.

Qualifications

  • Ph.D. in immunology, cancer biology or related field with 6+ years of industry experience in pharmacology for Senior Scientist or 3+ years for Scientist II
  • Expertise in formulation of small molecules, PK/PD assay technologies, and hit-to-lead optimization required
  • In vivo pharmacology expertise with xenograft or syngeneic tumor models required
  • Excellent hands-on in vivo skills: IV, PO dosing, tumor implantation, blood/tissue collection, etc.
  • Proven ability to manage junior scientists, external collaborations, and CROs
  • Experience with FACS-based characterization of immunity preferred
  • Novel in vivo model experience is a plus (e.g., CRISPR or humanized immune system mice)
  • Excellent communication and presentation skills
  • Excellent interpersonal skills and ability to work productively in a highly dynamic environment


Apply

Senior Research Associate, Preclinical Pharmacology – Discovery Biology

Position
We are seeking a highly skilled and motivated senior research associate to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology.

Primary Functions

The ideal candidate will have expertise in small molecule PK/PD and efficacy studies in oncology and inflammatory disease models. This individual will work closely with our drug discovery project scientists on late-stage lead optimization of novel compounds to support dose and schedule optimization, demonstrate in vivo efficacy, and characterize ex vivo immune cell function. The candidate must be self-driven, organized, able to work well with project scientists, and able to thrive in an exciting environment in a rapidly-growing company.

Qualifications

  • B.S. in immunology, biology or related field with 8+ years of industry experience
  • In vivo expertise with tumor models and/or autoimmune disease models required
  • Expertise in FACS-based immune cell phenotyping
  • Skilled at ex vivo functional assays for T cells, NK cells, and/or macrophage
  • Experience with formulation of small molecules and rodent PK/PD studies preferred
  • Excellent hands-on in vivo skills: IV, PO dosing, tumor implantation, blood/tissue collection, etc.
  • Ability to manage projects with CROs
  • Excellent communication and presentation skills
  • Excellent interpersonal skills and ability to work productively in a highly dynamic environment


Apply

Nurix, Inc. is a science-focused and goal-oriented organization that is committed to bringing breakthrough therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein homeostasis – a function vital to the healthy life of a cell – offering therapeutic opportunities in multiple disease areas. The Nurix scientific team has established an innovative drug discovery platform to identify selective inhibitors or activators of the UPS, enabling the development of new class of drugs that can restore normal cellular protein homeostasis. Nurix was founded by internationally-recognized experts in the UPS field and received its initial funding from leading life science investors, Third Rock Ventures and The Column Group. The Company recently entered into a multi-year strategic collaboration with Celgene for the discovery and development of new therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology. Nurix is based in San Francisco, California.

We are an equal opportunity employer offering a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the US. Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited