Scientist II, Protein Sciences

Position

We are seeking a highly skilled and motivated Scientist with expertise in Protein Sciences to join Nurix’s Discovery team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in the areas of oncology and immuno-oncology, by utilizing the mechanistic and structural insights to guide drug discovery efforts. The successful candidate will provide scientific leadership in Nurix’s protein expression and purification efforts to support biochemical, biophysical and structural efforts. This person will play a key role in the implementation of higher throughput methodologies to expand protein sciences capabilities. This individual will work closely with an experienced team of interdisciplinary scientists and have regular opportunities present findings to the project team and senior management. The candidate should have a strong desire to learn new techniques and the ability to incorporate new methodologies into their work. The ideal candidate will be self-driven, resourceful, very organized and focused, and enjoy working in a dynamic team environment.

Qualifications

  • Ph.D. in Biochemistry, Cell and Molecular Biology, or related field with 3+ years post-degree industry experience
  • Expertise in construct design, protein expression & purification, and protein characterization pertinent to small molecule drug discovery
  • Experience with protein production including multiprotein complexes in bacterial, baculovirus and mammalian expression systems
  • Knowledge of expression platforms, purification systems and analytical techniques (e.g. Wave bioreactor, AKTA, HPLC/MS, TFF)
  • Familiarity with the development of higher throughput methodologies and automated technologies for protein purification
  • A strong track record (publications, industry experience) with excellent interpersonal skills and ability to work in a team environment
  • The successful candidate will be aligned to Nurix’s culture and values; he/she will be team oriented and highly collaborative with a hands-on approach
  • The candidate should be enthusiastic, driven, have the ability to work independently and thrive in a dynamic start-up environment.


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Research Associate - Senior Research Associate, In Vivo Pharmacology – Discovery Biology

Position

We are seeking a highly skilled and motivated Research Associate/Senior Research Associate to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology. The ideal candidate will have expertise in small molecule PK/PD and efficacy studies in oncology or immuno-oncology.

Primary Functions

This individual will work closely with our drug discovery project scientists on late-stage lead optimization of novel compounds to support dose and schedule optimization, execution of pharmacodynamic biomarker assays, in vivo efficacy, and characterization of ex vivo immune cell function. The candidate must be self-driven, organized, able to work well with project scientists, and able to thrive in an exciting environment in a rapidly-growing company.

Qualifications

  • B.S. in immunology, cancer biology or related field with 1-2+ years (RA) or 8+ years of industry experience (SRA)
  • In vivo pharmacology expertise with xenograft or syngeneic tumor models required
  • Experience with formulating and dosing of small molecules and rodent PK/PD studies preferred
  • Excellent hands-on in vivo skills: IV, PO dosing, tumor implantation, blood/tissue collection, etc.
  • Experience in flow cytometry desired
  • Excellent communication and presentation skills
  • Excellent interpersonal skills and ability to work productively in a highly dynamic environment

Fit with Nurix Culture and Values

  • Team orientation; highly collaborative; solutions and results-oriented focus
  • Strong scientific curiosity and initiative; hands-on and resourceful
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment


Apply

Scientist I, In Vivo Pharmacology – Discovery Biology

Position

We are seeking a highly skilled and motivated in vivo pharmacologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology. The ideal candidate will have expertise in small molecule PK/PD studies in oncology and/or immuno-oncology.

Primary Functions

This individual will work closely with our drug discovery project scientists on late-stage lead optimization of novel compounds to evaluate PK/PD relationships, in vivo efficacy and ex vivo immune cell function. The candidate must be self-driven, organized, able to work well with project scientists, and able to thrive in an exciting environment in a rapidly-growing company.

Qualifications

  • Ph.D. in immunology, cancer biology or related field with 0-3 years of industry experience
  • Expertise in the in vivo evaluation of small molecules, PK/PD assay technologies, and hit-to-lead optimization required
  • In vivo pharmacology expertise with xenograft or syngeneic tumor models required
  • Excellent hands-on in vivo skills: IV, PO dosing, tumor implantation, blood/tissue collection, etc.
  • Proven ability to manage junior scientists, external collaborations, and CROs
  • Experience with FACS-based characterization of immunity preferred
  • Novel in vivo model experience is a plus (e.g., CRISPR or humanized immune system mice)
  • Excellent communication and presentation skills
  • Excellent interpersonal skills and ability to work productively in a highly dynamic environment

Fit with Nurix Culture and Values

  • Team orientation; highly collaborative; solutions and results-oriented focus
  • Strong scientific curiosity and initiative; hands-on and resourceful
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment


Apply

Nurix, Inc. is a science-focused and goal-oriented organization that is committed to bringing breakthrough therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein homeostasis – a function vital to the healthy life of a cell – offering therapeutic opportunities in multiple disease areas. The Nurix scientific team has established an innovative drug discovery platform to identify selective inhibitors or activators of the UPS, enabling the development of new class of drugs that can restore normal cellular protein homeostasis. Nurix was founded by internationally-recognized experts in the UPS field and received its initial funding from leading life science investors, Third Rock Ventures and The Column Group. The Company recently entered into a multi-year strategic collaboration with Celgene for the discovery and development of new therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology. Nurix is based in San Francisco, California.

We are an equal opportunity employer offering a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the US. Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited