TIM KUTZKEY, Ph.D.
Tim Kutzkey, Ph.D., is the Chairman of Nurix’s board of directors and also serves as the Interim President. He is a Partner at The Column Group and has contributed to the conception, formation and launch of several portfolio companies. He formerly was a scientist at KAI Pharmaceuticals, where his research focused on cell assay and pharmacodynamic marker development for selective protein kinase C inhibitors. Prior to KAI, Dr. Kutzkey studied at the University of California, Berkeley as a graduate student and postdoctoral scholar in the lab of Dr. Robert Tjian. He completed his Ph.D. on the biochemistry and genetics of long-range gene regulatory mechanisms. Dr. Kutzkey completed his undergraduate education at Stanford University.
ARTHUR T. SANDS, M.D., Ph.D.
Chief Executive Officer and Board Director
Arthur T. Sands, M.D., Ph.D., serves as the Chief Executive Officer at Nurix and is a member of the company’s board of directors. Prior to joining Nurix, Dr. Sands co-founded Lexicon Pharmaceuticals and served as President, Chief Executive Officer and a Director since 1995. At Lexicon, Dr. Sands pioneered the development of large-scale gene knockout technology for use in drug discovery and guided the evolution of Lexicon from a research-stage company to a drug development company, catalyzed by numerous alliances with Bristol Myers Squibb, Takeda and Genentech, and generating more than $450 million in revenue. Dr. Sands serves as Adjunct Professor in the Department of Human and Molecular Genetics at Baylor College of Medicine. He has also published many scientific and medical articles and is an inventor on numerous patents related to the discovery of human genes and their use in the development of new therapies. Dr. Sands holds an M.D. and a Ph.D. from Baylor College of Medicine and a B.A. in economics and political science from Yale University.
DAVID LACEY, M.D.
David Lacey joined Amgen in 1994 where, during the last five years of his tenure, he was the Head of Discovery Research, and managed more than 1200 employees. At any given time, Dr. Lacey oversaw over 100 actively-managed preclinical projects across four therapeutic areas: hematology/oncology, inflammation, metabolic disorders and neuroscience. Scientifically, he played a fundamental role in the discovery of the OPG/RANKL/RANK pathway at Amgen, which led to the development of the anti-RANKL human mAb denosumab, a blockbuster for both osteoporosis (Prolia) and cancer-related bone diseases (XGEVA) that had combined sales of $72 billion in 2015. Following his retirement in 2011, he has continued to be active in the biopharmaceutical industry. His current activities include advising academic institutions, biotechnology companies and venture capital firms. Dr. Lacey received both his undergraduate and medical degrees from the University of Colorado. Following the completion of his training, he served on the faculty at Washington University in St. Louis.
Perry Karsen served as the CEO of Celgene Cellular Therapeutics from 2013 until his retirement from Celgene at the end of 2015. Mr. Karsen also held positions of increasing responsibility at Celgene Corporation as Executive Vice President and Chief Operations Officer, and previously served as Senior Vice President, Head of Worldwide Business Development and President of the company’s Asia/Pacific region. Previously, he was the President and CEO of Pearl Therapeutics, a privately-held biotechnology company that was acquired by Astra-Zeneca in 2013. Mr. Karsen also held executive positions at Human Genome Sciences, Bristol-Myers Squibb Co., Genentech, Inc. and Abbott Laboratories, and was a General Partner at Pequot Ventures, focusing on investments in biotechnology and medical devices. Mr. Karsen received a masters of management from Northwestern University, Kellogg School of Management, a masters in teaching of biology from Duke University and a B.S. in biological sciences from the University of Illinois, Urbana-Champaign. Mr. Karsen will represent Third Rock Ventures on the Nurix board.
ROBERT TJIAN, Ph.D.
Dr. Tjian joined The Column Group as a Discovery Partner in September 2016. Prior to that he served as President of the Howard Hughes Medical Institute from 2009-2016. Dr. Tjian discovered the first transcription factors, human proteins that bind to specific sections of DNA and play a critical role in regulating how genetic information is expressed into the thousands of biomolecules that keep cells, tissues and organisms alive. Dr. Tjian's laboratory has focused on disruptions in the process of transcription that cause diseases such as cancer, metabolic syndromes and neuro-degenerative diseases. Dr. Tjian joined the University of California, Berkeley faculty in 1979, where he assumed several leadership roles, including Director of the Berkeley Stem Cell Center, Faculty Director of the Li Ka Shing Center for Biomedical and Health Sciences, and Head of the Siebel Stem Initiative. He currently serves as scientific advisor to the Chan Zuckerberg Initiative and the BioHub. Dr. Tjian is a member of the National Academy of Sciences and has received numerous awards including the Alfred P. Sloan Prize and the Louisa Gross Horwitz Prize.